Results
| PMID | 11821086 |
| Gene Name | KIR2DL1 |
| Condition | Endometriosis (Pelvic) |
| Association |
Associated |
| Population size | 40 |
| Population details | 40 women with other laparoscopic diagnoses, women diagnosed with endometriosis |
| Sex | Female |
| Associated genes | KIR2DL1 |
| Other associated phenotypes |
Pelvic endometriosis |
|
Fertil Steril. 2002 Feb;77(2):297-302. Maeda, Nagamasa| Izumiya, Chiaki| Yamamoto, Yorito| Oguri, Hiroyoshi| Kusume, Tomoaki| Fukaya, Takao Department of Obstetrics and Gynecology, Kochi Medical School, Oko, Nankoku, Kochi, Japan 783-8505. maedan@med.kochi-ms.ac.jp OBJECTIVE: To investigate the host immunologic response to endometriosis in terms of killer inhibitory receptor (KIR) expression by natural killer (NK) cells. DESIGN: Case-control study of immunologic markers. SETTING: University hospital. PATIENT(S): We compared cells from Japanese women with laparoscopically diagnosed endometriosis to cells from 40 women with other laparoscopic diagnoses. INTERVENTION(S): Peripheral venous blood sampling and laparoscopic peritoneal fluid collection. MAIN OUTCOME MEASURE(S): Flow cytometry was used to assess expression of KIR by NK cells in the cell samples. RESULT(S): The percentage of cells that expressed KIR2DL1 among NK (KIR2DL1(+)NK) cells in peritoneal fluid and peripheral blood was significantly higher in women with endometriosis than in controls. The proportion of KIR2DL1(+)NK cells in peripheral blood NK cells before and 1 month after laparoscopic surgery did not differ significantly. CONCLUSION(S): The proportion of KIR2DL1(+)NK cells was increased in peritoneal fluid and peripheral blood in women with endometriosis; this difference is probably related to NK cell suppression in endometriosis. This increase in KIR2DL1 expression by NK cells may represent a risk factor in the pathogenesis of endometriosis. Mesh Terms: Adult| Antigens, CD/biosynthesis/blood| Ascitic Fluid/chemistry| Case-Control Studies| Endometriosis/blood/*immunology/metabolism| Female| Flow Cytometry| Humans| Japan| Killer Cells, Natural/*immunology/metabolism| *Lectins, C-Type| Membrane G |
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